The Palacio de Santa Cruz is an Early Renaissance palace in Valladolid, in Castile and León, Spain, built as a "college" for the University of Valladolid, who still own it. Construction began in 1486 but from 1490 building came under the supervision of Lorenzo Vázquez de Segovia who finally completed it in 1491.
It now houses the offices of the Rector and his staff, and two university museums, one of African art. The library collection includes the Valcavado Beatus manuscript.
Founded by Cardinal Mendoza, the college is considered to be the earliest extant building of the Spanish Renaissance.
Wikipedia https://en.wikipedia.org/wiki/Palacio_de_Santa_Cruz
Address 8 Plaza del Colegio de Santa Cruz, Valladolid 47002, Spain
Coordinates 41°39'5.754" N -4°43'11.857" E