Perseus with the Head of Medusa

Perseus with the Head of Medusa is a bronze sculpture made by Benvenuto Cellini in the period 1545–1554. The sculpture stands on a square base which has bronze relief panels depicting the story of Perseus and Andromeda, similar to a predella on an altarpiece. It is located in the Loggia dei Lanzi in the Piazza della Signoria in Florence, Italy. The second Florentine duke, Cosimo I de' Medici, commissioned the work with specific political connections to the other sculptural works in the piazza. When the piece was revealed to the public on 27 April 1554, Michelangelo's David, Bandinelli's Hercules and Cacus, and Donatello's Judith and Holofernes were already installed in the piazza.

The subject matter of the work is the mythological story of Perseus beheading Medusa, a hideous woman-faced Gorgon whose hair had been turned to snakes; anyone who looked at her was turned to stone.