This neighborhood used to be inhabited by German, Polish, Italian, and Czech immigrants. That is why it is called like the famous Czech city - Pilsen. If you like street art, you should definitely visit this district - it is full of colorful murals usually with some powerful message.
Wikipedia https://en.wikipedia.org/wiki/Lower_West_Side,_Chicago
Coordinates 41°51'27.118" N -87°39'27.19" E